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Admin13.07.2021

The multiple personalities of Alix

TSG101 ESCRT-I UEV domain P 717SAP 720 MVB sorting and viral budding CHMP4 ESCRT-III Unknown Bro 1, domain, Patch 1 MVB sorting and viral budding Gag YPx nL Unknown Viral budding SETA SH3 domain P 740TPAPR 745 Growth factor receptor endocytosis; focal adhesion remodeling Endophilin SH3 domain P 755ARPPPP 761 Growth factor receptor endocytosis Src SH2 domain Phospho-Y 319 Growth factor receptor endocytosis; focal adhesion remodeling Src SH3 domain P 752QPPAR 757 Growth factor receptor endocytosis; focal adhesion remodeling ALG-2 Unknown PGY repeats aa 802-813 Apoptosis Overview of the cellular mechanisms involving Alix.
Admin27.07.2021

Meaghan Schmidt

A Alix inhibits association of the SETA-endophilin complex with Cbl and reduces Cbl-mediated ubiquitylation of EGFR, SETA and Cbl itself.
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Admin15.06.2021

Meaghan Schmidt

Collectively, class E Vps proteins function at the cytosolic face of endosomal membranes to sort integral membrane proteins into lumenal vesicles following invagination of the endosomal membrane.
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Admin23.07.2021

The multiple personalities of Alix

Model for the negative regulation of EGFR endocytosis by Alix.
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Admin14.06.2021

The multiple personalities of Alix

The production of EIAV virions is strongly inhibited by overexpression of truncated Alix fragments ; or by silencing Alix expression by RNAi.
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Admin12.06.2021

The multiple personalities of Alix

The diversity of Alix functions is due to its proline-rich C-terminus, which provides multiple protein-binding sites.
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Admin04.09.2021

The multiple personalities of Alix

In fact, despite its intimate connections with the ESCRT machinery, whether Alix has any role in MVB sorting has been questioned because degradation of the epidermal growth factor receptor EGFR , long known to be an MVB cargo, is not blocked by RNA silencing of Alix ; ;.
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Admin24.06.2021

Meaghan Schmidt

Alternatively, it might interfere with the ability of SETA to promote focal adhesion formation, which would be similar to the way in which Alix restricts SETA from promoting EGFR endocytosis.
Admin21.06.2021

Meaghan Schmidt

In most cases, the lumenal vesicles are delivered into the hydrolytic interior of the lysosome after fusion of the MVB perimeter membrane with the lysosomal membrane ; ;.
Admin10.06.2021

The multiple personalities of Alix

Although Alix appears to participate directly in these various activities, the role it plays in each process has largely been inferred from the functions of proteins with which it interacts.
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